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Description

TB-500s biological activity is mediated primarily through binding of the LKKTETQ actin-binding motif to G-actin and sequestering actin monomers, regulating actin polymerisation dynamics, and activating downstream signalling through the PI3K/Akt pathway that promotes cell survival, migration, and proliferation in multiple cell types relevant to tissue repair including endothelial cells, fibroblasts, keratinocytes, and myocytes

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Introduction Patients affected by chronic kidney disease (CKD) or end-stage renal disease (ESRD) have a shorter life expectancy than those with normal renal function, primarily due to the dramatic increase in cardiovascular mortality [1]

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