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In patients with lipedema, this technique revealed changes in superficial lymph flow, such as slow flow, an increased number of abnormal lymphatic vessels, and higher fluorescent intensity in the skin 83

The C-terminal segments of each B-chain come together to form an antiparallel -sheet (residues B24-B28 and its dimer-related mates)

This is the most frequently seen variant

The varied arrangements may reflect the need to allow passage of interstitial fluid to the local lymphatics

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Lazou K, Sadick NS, Kurfurst R, et al