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In addition, as mentioned in Section Errors in the protein synthesis pathway, the age- and AD-associated increases in +1-frameshifted ubiquitin B can block polyubiquitination and lead to an impairment in UPS function

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(2017) www.sciencedaily.com From the article: The researchers followed a group of men for eight years who had been on TTh [testosterone therapy] and compared them with another group of men who remained untreated for the same time period
