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Plasma and red blood cell membrane accretion and pharmacokinetics of RT001 (bis-allylic 11,11-D2-linoleic acid ethyl ester) during long term dosing in patients

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10.1002/hep.28526 104

The free energy change in several of these steps is very exergonic

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Moreover, multiple in vitro (64,65) and in vivo (66,67) studies suggest that ergothioneine activates the transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2), which triggers the cellular antioxidant defence system