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Also, LPS increased glycolysis in macrophages, coinciding with an increased GLUT1 and hexokinase expression and increased absorption of F-fluorodeoxyglucose (Mills et al., 2016)

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Upon cellular stress, characteristic of ASD [158], ROS production and elevated intracellular Ca 2+ concentration trigger mPTP opening leading to mitochondrial membrane permeabilization (MMP) [181], initiating apoptosis and necrosis [269], and regulating the activity of autophagy [270, 271]

thus, forming a feed-forward loop that enhances tumorigenesis

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Yolk sac macrophage progenitors traffic to the embryo during defined stages of development