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The trial sample size was chosen on the basis of the robust efficacy of ARA 290 in a rodent model of neuropathy (12) and from the observations derived from a prior small nonblinded trial of 20 patients with symptoms of SFN who received ARA 290 (2 mg intravenously) for three doses every 2 d over 1 wk (11)

10.3389/fnins.2017.00227 32 DengZ.WangY.LiuJ.ZhangH.ZhouL.ZhaoH.et al (2023)

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Structural basis of mitochondrial receptor binding and constriction by DRP1