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This imbalance leads to an increase in harmful substances such as lipopolysaccharide (LPS) and heightened activity of pro-inflammatory factors

Sufficient nutrient availability continues to be required for motility, DNA quality and fertilization ability

People over 65 Age-related changes in stomach acid production reduce the ability to absorb B12 from food

While glutathione is generally safe, some individuals may experience mild side effects

However, several critical gaps currently limit its translation into clinical practice: (1) the lack of sensitive and standardized biomarkers for early detection of bioenergetic deficits, (2) limited incorporation of creatine profiling into predictive risk models, (3) insufficient personalization of supplementation strategies despite known interindividual variability in transporter function, endogenous synthesis, and tissue kinetics, and (4) underdeveloped clinical validation of advanced creatine formulations and delivery systems