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166 The effect of the microbiome on the recruitment and gene expression of tissue-resident myeloid cells is accomplished primarily by the regulation of local metabolites and tissue mediators

Enhances Bone and Joint Health Preliminary evidence suggests that IGF-1 LR3 supports bone health and joint function by stimulating bone density through increased cellular activity and regeneration

Keywords: autoantibodies, cerebellar ataxia, encephalitis, GAD autoimmunity, hyperexcitability, stiff person syndrome Introduction GAD (glutamic acid decarboxylase) is a pyridoxal 5-phosphate-dependent enzyme, widely expressed within the central nervous system and pancreatic -cells, that catalyzes the conversion of the excitatory neurotransmitter l-glutamate to the inhibitory neurotransmitter gamma-aminobutyric acid (GABA)