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Research indicates that NNMT expression correlates positively with insulin resistance, with plasma levels of the NNMT product 1-methylnicotinamide associated with increased body mass index and metabolic dysfunction

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Shoelson S

Does not significantly inhibit related SAM-dependent methyltransferases or enzymes in the NAD+ salvage pathway NAD+ increase : By preventing nicotinamide methylation to 1-MNA, more nicotinamide remains available for conversion to NMN and subsequently to NAD+ via the salvage pathway

AOD 9604 was actually developed far enough to go through human clinical trials for obesity treatment

Obese individuals may require doses at the higher end of the range, though this should be done under medical supervision

This distinction matters for peptide research applications