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Abp1 is involved in the recruitment of Actin (necessary for membrane invagination and vesicle formation) and therefore is associated with a productive endocytic event while its absence towards the end of Ent1/Ent2 lifetime would represent an abortive site

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(These statements have not been evaluated by the Food and Drug Administration

10.1016/j.nbd.2016.05.011 32 DollS.FreitasF

Once the glucuronide conjugation and sulfation pathways are saturated, excess acetaminophen is oxidized via the cytochrome P450 microsomal enzyme, resulting in the formation of NAPQI, a highly toxic metabolite [111]