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TMA is typically produced during the digestion of choline- and carnitine-rich foods, and it is normally metabolized by the liver enzyme flavin-containing monooxygenase 3 (FMO3) (Fig

Some toxicities, such as interstitial lung disease from abemaciclib, can be fatal, though rarely

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[DOI] [PubMed] [Google Scholar] Biolo G, Toigo G, Ciocchi B, Situlin R, Iscra F, Gullo A, Guarnieri G

However, it should be emphasized that the majority of mechanisms described below are well-established in general ED research, whereas their specific involvement in varicocele-associated ED is supported predominantly by indirect evidence and preclinical studies rather than direct human clinical data

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