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J Pediatr 119:491493

No regulatory authority has established clinical dosing guidelines

This finding is surprising because asparagine supplementation does not restore the levels of other NEAAs (alanine, proline, and glutamate) or any TCA cycle intermediates (-KG, malate, and fumarate)

Dietary choices play a crucial role, with plant-based diets potentially lacking this nutrient found predominantly in animal products

Our generation of pure GSS-CAM-TPP enabled us to assess whether this impacted our approach by quantifying any conversion of GSS-CAM-TPP to its corresponding thioether GS-CAM-TPP in the presence of TCEP (Supplementary Fig