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The application of NaBPC1 57 (10 g, 10 ng/kg b.w.), propranolol (10 mg/kg b.w.), and ranitidine (10 mg/kg b.w.) (control rats received an equivolume of saline 5.0 ml/kg), either intragastrically or intraperitoneally, was conducted either prophylactically (10 days before alcohol initiation) or as a co-treatment together with alcohol or therapeutically (starting at the end of a two month period, i.e

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[1] In the SURMOUNT-1 clinical trial, higher doses in non-diabetic adults demonstrated significant weight loss, with participants losing approximately 15-20% of body weight over 72 weeks