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The trial proceeded without reported toxicity, and no lethal dose threshold (LD1) was ever established in subsequent safety testing meaning researchers administering the compound could not find a dose that caused death in even 1% of test subjects across the animal model safety work that preceded and followed the human study

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Oral supplements may not also be best for those with acute B12 deficiency, as theres no way to tell how much is getting absorbed by the body

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