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J Immunol 186:18401848 Feng X, Zhang L, Acharya C, An G, Wen K, Qiu L et al (2017) Targeting CD38 suppresses induction and function of T regulatory cells to mitigate immunosuppression in multiple myeloma

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We now demonstrate that targeting CD38 with heavy-chain antibodies that selectively inhibit NAD glycohydrolase activity without inducing cell death or global CD38 blockade will boost tissue NAD + and precursor levels and sirtuin activity, reduce cellular senescence and mitigate fibrosis and inflammation in multiple organs

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