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40 Moreover, the inhibitory activities of these cyclic peptide inhibitors for NNMT were not affected by different concentrations of either NAM or SAM, suggesting that their interactions with NNMT were at an allosteric site other than the active site

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Since decreased Parasutterella relative abundance may accompany increased stress 80,81 , the increased Parasutterella relative abundance that occurred in this study following diet switch likely arose from the weight loss-mediated negative energy state