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Despite its vital role in healthcare, the well-being of the patient should always be the top priority
Bystander activation mainly occurs through two mechanisms

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References Stoner, G

In summary, tubulin binders are the most widely used payloads among ADCs, being selected for 8 out of 15 marketed ADCs (53.3%) and 11 out of 24 ADCs in phase III clinical trials (45.8%)

Collectively, the risk of developing breast cancer in the BRCA1 carriers in their lifetime is between 55% and 72%, whereas for BRCA2 it falls in between 45% and 69%