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Chung, S

Zinc Zinc, like iron, is involved in thyroid homeostasis, contributing to thyroid hormone synthesis and action at various levels: modulating TRH and TSH synthesis at the hypothalamic-pituitary level

This may be due to the higher catalytic efficiency of COMT in the formation of 4-methylated estrogens than 2-methylated estrogens and the difference in the kinetics of the two reactions 27

Alternative routes of administration include oral formulations, transdermal systems (gels and patches), and subcutaneous implants, which allow for more stable serum testosterone concentrations and individualized dosing strategies

Toxicology 227 , 94104 (2006)

Injectable: 12 mg daily for 1624 weeks minimum