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Description
Three designed analogues incorporated diselenide bonds at the native cross-links (614, 1628, and 2239), while a fourth analogue introduced a diselenide bridge at a non-native position (616), based on the proposed role of this non-native disulfide bond in the early stages of hirudin folding

however, these methods still only provide partial coverage of the metabolome (Wishart, 2011)

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Hill KE
et al (2014) Infect

doi: 10.1016/j.brainresbull.2025.111549 46 XianPWangMXieRMaHZhengWKangJet al