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6 Morin hydrate as an adjuvant to overcome cisplatin resistance and toxicity in liver cancer Cisplatin resistance in liver cancer is driven by PARP1-mediated autophagy via the HMGB1 pathway

Pharmacological inhibitors, such as Ferrostatin-1 (Fer-1), act by scavenging lipid-derived radicals and chelating labile Fe 2+ , thereby reducing oxidative stress and ferroptotic cell death [153]

Inhibition of growth hormone signaling by the fasting-induced hormone FGF21

Melatonin reduces GSH level and subsequent overproduction of ROS in human liver cell line HepG2 [152]

In combination with Cntf that induces astrocytic phenotypes alone, Igf-1 decreases Cntf-mediated differentiation [115]

[DOI] [PubMed] [Google Scholar] 223.Li P