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Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum JL

The two major nutrient-sensing pathways that have been identified as key modulators of DR-induced longevity are LET-363/mTOR (mechanistic target of rapamycin) and IIS (insulin/insulin-like growth factor 1) signaling

Includes: diabetes (mellitus) due to insulin secretory defect diabetes NOS insulin resistant diabetes (mellitus) Use additional code to identify control using: insulin (Z79.4) oral antidiabetic drugs (Z79.84) oral hypoglycemic drugs (Z79.84) Excludes1: DM due to underlying condition (E08.-) drug or chemical induced DM (E09.-) gestational diabetes (O24.4-) neonatal DM (P70.2) postpancreatectomy DM (E13.-) postprocedural DM (E13.-) secondary DM NEC (E13.-) type 1 DM (E10.-) E11.0 Type 2 DM with hyperosmolarity

10.1007/s00438-003-0900-9 Matyash V, Entchev EV, Mende F, Wilsch-Brauninger M, Thiele C, Schmidt AW, Knolker HJ, Ward S, Kurzchalia TV: Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16