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Consult Your Healthcare Provider If you experience excessive tiredness or nerve problems, your healthcare provider can do a blood test to check vitamin B12 levels and also rule out other potential causes for your symptoms

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doi: 10.3390/nu11051136

The deletion of PNPLA2 in adipocytes resulted in reduced PPAR activity and expression of target genes, including lower UCP1 protein levels and when exposed to cold, mice were cold sensitive (140)