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Use of mass spectrometry in deducing the sequence of somatostatin, a hypothalamic polypeptide that inhibits the secretion of growth hormone

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Hinman A, Holst CR, Latham JC, Bruegger JJ, Ulas G, McCusker KP, Amagata A, Davis D, Hoff KG, Kahn-Kirby AH, et al

[35] Since the presence of 1,4-dioxane was recognized, many manufacturers have implemented purification processes, such as vacuum and steam stripping, to reduce its concentration in finished products