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and (4) with no history of cerebrovascular disease

Once formed, AGEs can damage cellular structures through a number of mechanisms, including the formation of cross-links between key molecules of the basement membrane of the extracellular matrix and interaction with receptors on cell surfaces, leading to this way to alteration of cellular function [36, 37]

doi:10.7759/cureus.8506 Bordes S, Werner C, Mathkour M, McCormack E, Iwanaga J, Loukas M, Lammie M, Dumont AS, Tubbs RS

Theres ongoing research in this area

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