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Importantly, mTOR inhibition (e.g., via rapamycin) helps maintain astrocytes in a protective state and reduces neuronal lipid peroxidation damage (Zhang et al., 2025c)

Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1p

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Therefore, if left untreated, DED can become an irreversible chronic condition driven by reduced tear flow, increased evaporation, and repeated nerve stimulation