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The drug's mechanismworking centrally rather than peripherallyhas been suggested to potentially offer advantages for men whose ED has a psychological component, but this remains speculative without further research

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10.1038/nrm.2017.27 [DOI] [PMC free article] [PubMed] [Google Scholar] Berraondo P., Etxeberria I., Ponz-Sarvise M., Melero I

Patients are started on the lowest dose and titrated up as tolerated every four weeks

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