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Its core lies in leveraging highly expressed specific receptors on BBB endothelial cells to trigger energy-dependent active transport by ligand-receptor recognition, thus overcoming the constraints of an intact BBB (Figure 4B)

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Consequently, AZA was an immunosuppressive drug to lower organ rejection for the first successful cadaveric kidney transplant ( Even nowadays, the main challenge in organ transplantation is the increasing demand for organ transplants, which outstrips the supply