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Subsequently, unique gene hit counts were calculated using featureCounts from the Subread package v.1.5.2 by summarizing and reporting the hit counts based on the gene id feature in the annotation file 26

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Synthesis of the complete NAD + molecule is achieved via different biochemical pathways, namely the de novo synthesis, PreissHandler, salvage pathway, and the nicotinamide riboside kinase (NRK)-mediated salvage 2630 (Fig

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