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4.1 Epigenetic targeting and chromatin modifying therapies Epigenetic remodeling plays a pivotal role in driving reversible drug-tolerance phenotypes

Golfers elbow typically occurs due to repeated arm movements that put excessive strain on the flexor muscles tendon attaching to the inner aspect of the elbow

When ascorbic acid is oxidized, it forms semidehydroascorbate (1 degree of oxidation) and then dehydroascorbate (2 degrees of oxidation)

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Inhalation avoids hepatic first-pass metabolism and the lungs have lower enzymatic activity than other organs [97]

74 Chronic overnutrition, a sedentary lifestyle and IR in adipose tissue can directly lead to the production and accumulation of excess toxic lipid products (such as diacylglycerol, ceramides, and NEFAs), and the metabolites can aggravate the ectopic lipid deposition through some signaling pathways (such as mTOR and notch)