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Xiaodong Chen, Huazhong Agricultural University, China

Alopecia, Page 16 and 17: Session Information 10 10

Psychopharmacology 234:23112323

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Valproate-induced acute liver failure and liver-related deaths have been reported in patients with hereditary neurometabolic syndromes caused by mutations in the gene for mitochondrial DNA polymerase (POLG) (e.g., Alpers- Huttenlocher Syndrome) at a higher rate than those without these syndromes

To overcome these limitations, RK is currently synthesized chemically via the condensation of p-hydroxybenzaldehyde with acetone or biosynthesized in genetically modified microorganisms such as bacteria or yeast