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Although early NAC treatment is beneficial in limiting the injury, continuous NAC treatment well beyond the injury phase can delay regeneration [72] mainly through impairment of mitochondrial biogenesis, an adaptive response whose role is to maintain or restore homeostasis following mitochondrial dysfunction [71]

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Caffeine, with its neuroprotective properties, is thought to be a key factor

TEM is one of the most powerful techniques that uses an electron beam

Free water determines diffusion alterations and clinical status in cerebral small vessel disease

8 weeks (1 vial): 12 mL 1 10 mL bottle 12 weeks (2 vials): 24 mL 1 10 mL bottle 16 weeks (3 vials): 36 mL 1 10 mL bottle Alcohol Swabs One for the vial stopper + one for the injection site each week