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STORY AT-A-GLANCE Japanese professor Toru Miyazaki has discovered a potential trigger for feline chronic kidney disease (CKD) that involves the protein AIM (apoptosis inhibitor of macrophage), also known as CD5-like (CD5L) AIM is a secreted protein in the blood that supports kidney health by identifying, destroying, and removing dead cells and other debris that accumulate in the body In many cats, it seems the AIM protein cant do its job properly because it binds too tightly to IgM [immunoglobulin M] antibodies, which impedes its ability to dissociate from the antibodies and attach to the problematic debris to initiate the cleansing process Miyazaki has collaborated with both an ultraprocessed pet food producer and a pharmaceutical company in Japan to develop a food+drug companion therapy to prevent and treat CKD in cats

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Huang et al., 2024), modulating the inflammatory process in colitis

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Neuroprotection research includes hippocampal ischemia-reperfusion models in rats (PMID 32558293) and investigations into the brain-gut axis as a candidate explanatory framework for the broad effects observed across tissue types (PMID 27138887)