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To elucidate the pathomechanistic background in HFpEF manifestation robust preclinical models encompassing cofactors and comorbidities are needed [6]

Similar results were reported in the clinical study of patients with type 2 diabetes, where increased TMAO levels are independently associated with risks of adverse cardiovascular events (138, 139)

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Lastly, a systematic review and meta-analysis published in Thyroid in 2016 found that selenium significantly reduced thyroid autoantibodies in people with chronic autoimmune thyroiditis