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When it comes to male fertility, a huge number of alternative treatments, ranging from specific natural supplements to eating more avocados or oysters, have been found by small, uncontrolled studies to potentially be associated with an improvement in semen parameters

Plant J 50:128139 Nenova V, Bogoeva I (2014) Separate and combined effects of excess copper and Fusarium culmorum infection on growth and antioxidative enzymes in wheat ( Triticum aestivum L.) plants

This produces mutagenic and carcinogenic byproducts, including 8-hydroxy-2-deoxyguanosine (8-OHdG), 4-hydroxy-nonenal (4HNE) modifications, and malondialdehyde (MDA), resulting in lipid peroxidation, protein modification, and DNA oxidative damage 60

Conversely, cartilage-specific overexpression of GPX4 via transgenic technology, or restoration of its activity using small molecule drugs such as certain natural compounds or ferroptosis inhibitors, can significantly delay cartilage degeneration, improve subchondral bone sclerosis and osteophyte formation, and alleviate synovitis in model animals (Xiao et al., 2024), which directly confirms the protective role of GPX4 in OA progression from a gain-of-function perspective

Sulli et al

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