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Knowledge of the PK-PD profile of neuroprotective drugs at the BBB/BCSFB level may be helpful to improve the therapeutic window of opportunity to treat TBI and other CNS diseases

IV or high-dose oral glutathione may benefit neurological conditions like Parkinsons disease according to clinical protocols

Moreover, it was found that the combination of FA (40 mg/mL) and genistein (27 mg/mL) in the treatment of Ab31-35-exposed rat cortical neuron cultures showed an enhanced neuroprotective effect by down-regulating the apoptotic-related genes Bax, p53, and caspase3 and up-regulating Bcl-2 [126]

[DOI] [PubMed] [Google Scholar] Bergstrm S

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Moreover, the administration of different anticancer drugs, including OHP, also showed this pathological event, and the preliminary effects of henna on CIPN have been evaluated (NCT04201587)