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Non-motor symptoms in Parkinson's disease encompass a variety of functions, such as disturbances in sleep-wake cycle regulation, cognitive dysfunction (such as frontal executive dysfunction, memory retrieval problems, dementia, and hallucinations), mood and affect disorders, autonomic dysfunction (primarily orthostatic hypotension, urogenital dysfunction, constipation, and excessive sweating), sensory symptoms (especially reduced sense of smell), and pain

These changes can lead to an imbalance in transport mechanisms and intercellular junctional molecule expression, elevation of proinflammatory cytokine levels, and disruption of blood flow, all exacerbating disease progression [12]

MHC, Major histocompatibility complex

This prompted plants in turn to develop intracellular receptors (R proteins) that recognize the pathogen/pest effector(s) and initiate an additional level of defense termed effector-triggered immunity (ETI) 15,16

Type 2 diabetics may be particularly vulnerable to decreases in antioxidants and increases in inflammatory markers