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A Brief History of GH Secretagogues The GH secretagogue story begins in the 1970s when Cyril Bowers discovered that small synthetic peptides based on enkephalin could release GH from pituitary cells without acting through opioid receptors

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Collectively, they offer a crosslevel perspective that links molecular disruptions with clinical manifestations

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By themselves, GH stimulating peptides lead to improvements in body composition, with a loss of fat and an increase in muscle mass, but overall weight loss is limited