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4 Hospital Universitario Central de Asturias, Infectious Diseases Unit, Oviedo, Spain, 5 Hospital Universitario Central de Asturias, Infectious Disease Unit, Oviedo, Spain Introduction: The increasing antibiotic resistance in microorganisms urged interventions such as the antibiotic stewardship programs in ICU focused on reducing the inappropriate use of antibiotics by improving the antibiotic selection, the dosage, administration route and length as well as improving clinical outcomes and reducing antibiotic resistance

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A 20 l sample was injected using an autosampler (Model 542