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MAT1 KO hepatocytes can also be detected with reduced methylation/CYP2E1 ratio, reduced mitochondrial membrane potential, increased ROS content, and are sensitive to ethanol and TNF--induced mitochondrial dysfunction

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Consistent with observations in Fig

ROS interfere with the synthesis of new collagen, which is responsible for rebuilding and strengthening skin structures as well as tissue regeneration

Retinal flicker sensitivity, a marker of macular health, improved with saffron but not placebo (Falsini 2010)

Endogenous peroxidase was blocked with 3% H 2 O 2 for 10 min, followed by incubation with normal goat serum for 60 min at 37