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Yoshida, T., Watanabe, M., Engelman, D.T., Engelman, R.M., Schley, J.A., Maulik, N., Ho, Y.S., Oberley, T.D

K., Schein P

A crucial and often overlooked factor in ME/CFS and Long COVID management is the "energy cost of digestion." Digesting solid food, particularly dense proteins like meat or standard dairy, requires a massive amount of ATP energy and blood flow directed to the splanchnic (gut) region

Lu, S.C., et al., Insulin and Glucocorticoid Dependence of Hepatic Gamma-Glutamylcysteine Synthetase and Glutathione Synthesis in the Rat Studies in Cultured-Hepatocytes and Invivo

As the prevalence of diabetes increases, so does the prevalence of DKD

Thus, oxidative imbalance should be viewed as a convergent driver that links MNPs-triggered NOXs activation and mitochondrial dysfunction, and primes downstream inflammation and cell death