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Acknowledgments We acknowledge SRM Institute of Science & Technology, Kattankulathur, India for providing infrastructure support

Clinical research demonstrates that glutathione supplementation provides significant cellular protection and reduces oxidative damage throughout the body.* MTHFR variants directly impair methylation efficiency, reducing each cell's capacity to produce adequate glutathione

Concomitant effects of Ramadan fasting and time-of-day on apolipoprotein AI, B, Lp-a and homocysteine responses during aerobic exercise in Tunisian soccer players

Critically, smart designs incorporating stimuli-responsive elements (pH-, redox-, or enzyme-triggered release) and active targeting ligands (e.g., folate, transferrin, hyaluronic acid, RGD peptides) enable spatiotemporal control over drug release, significantly improving tumor-specific uptake and minimizing off-target toxicity

doi: 10.1016/j.lfs.2022.120805 32

Iran Biomed J