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Shuai ZhaShuai ZhaHubei University of Chinese Medicine, School of Laboratory Medicine, 16 Huangjia Lake West Road, Wuhan 430065, ChinaHubei Shizhen Laboratory, Wuhan 430061, ChinaMore by Shuai Zha Haitao LiuHaitao LiuHong Kong Baptist University, Department of Chemistry, Ho Sin Hang Campus, 224 Waterloo Road, Kowloon, Hong Kong SAR 999077, ChinaMore by Haitao Liu Hengde LiHengde LiHong Kong Baptist University, Department of Chemistry, Ho Sin Hang Campus, 224 Waterloo Road, Kowloon, Hong Kong SAR 999077, ChinaMore by Hengde Li Haolan LiHaolan LiDalian University of Technology School of Chemical Engineering, Lingshui Street, Ganjingzi District, Dalian 116024, ChinaMore by Haolan Li Ka-Leung Wong * Ka-Leung WongThe Hong Kong Polytechnic University Department of Applied Biology and Chemical Technology, Building Y815, 11 Yuk Choi Road, Hung Hom, Kowloon, Hong Kong SAR 999077, China * E-mail: [email protected]More by Ka-Leung Wong Angelo Homayoun All * Angelo Homayoun AllHong Kong Baptist University, Department of Chemistry, Ho Sin Hang Campus, 224 Waterloo Road, Kowloon, Hong Kong SAR 999077, China * Email: [email protected]More by Angelo Homayoun All Abstract The bloodbrain barrier (BBB) is a specialized semipermeable structure that highly regulates exchanges between the central nervous system parenchyma and blood vessels

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4 DNA methylation mechanisms A conserved family of cytosine methylase enzymes called DNA methyltransferases (DNMTs) catalyze DNA methylation, typically transferring methyl groups from a molecule known as methyl donor S-adenosine methionine (SAM) to a cytosines fifth carbon position

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