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Furthermore, only fecal ileal samples from mice immunized with CII + CFA, but not from the other regimen increased gut permeability (based on lactulose/mannitol ratio measurements) (Fig

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Potential risks and contraindications Given the limited understanding of DSIPs mechanisms and effects in humans, certain risks and contraindications must be taken into consideration: Unknown long-term effects : The long-term safety of DSIP has not been well-established, and the potential risks associated with chronic use remain unclear