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The survival and activation/proliferation of OPCs, as well as and their enhanced and continuous differentiation into Enpp6 -positive newly-forming/formed OLs, despite the late onset (from 2-3 weeks and beyond) demyelination under the continuous pressure of CPZ, underpinned a strong potential for remyelination after CPZ withdrawal

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Changes often interpreted as angiogenesis may instead reflect alternative vascular phenomena such as remodeling, pericyte dropout, thickening of the basement membrane, or BBB disruption without true neovascularization (Sweeney et al