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Description
Research interest nonetheless expanded considerably through the 1980s and 1990s, as investigators began exploring DSIP's broader neuroendocrine roles, including its interactions with the HPA axis, circadian timing systems, and stress-response pathways, establishing the compound as a multifunctional regulatory neuropeptide whose biological significance extends well beyond its original sleep-focused characterization

however, significant research gaps remain, particularly in the areas of lipidomics and proteomics

While these side effects are short-term and may resolve themselves with a few nights of proper sleep, continued sleep deprivation may contribute to long-lasting health complications

e) no multi-ingredients supplementation

Clin Trans Gastroenterol

Updated April 22, 2025