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Under oxidative stress conditions, NRF2 separates from Keap1 and activates the expression of downstream target genes containing antioxidant response elements (ARE), such as iron heavy chain protein (FTH1) and iron light chain protein (FTL), promoting GSH synthesis and regenerating NADPH to exceed ROS production (83)

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Advantages of peptides: Lower risk of shutdown (your natural production continues) More targeted effects (specific signaling pathways) Often fewer side effects Can be cycled on and off more easily When hormone replacement makes more sense: Severe hormone deficiency that peptides alone cant fix Faster, more dramatic results needed Combined with peptides for synergistic effects At Blueline Wellness Group, we often recommend both

doi: 10.3390/antiox10030376 8 VoiculescuSEZygouropoulosNZahiuCDZagreanAM

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Another model to assess the relative importance of endocrine versus paracrine/autocrine IGF-I is the liver-specific Ghr ko mouse