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Its not that the local kid has played badly
Since melatonin is mainly metabolized by cytochrome P450 (CYP) 1A2 and CYP2C19, inhibitors of these enzymes lead to higher concentration of melatonin in the body [42]

Mitochondrial dysfunction in HD includes impaired electron transport chain activity, reduced mitochondrial biogenesis, and defective mitophagy, all of which contribute to increased oxidative stress and neuronal damage [165]

doi: 10.1186/1750-1172-7-S1-S4

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ABCDE Mnemonic (Asymmetry, Border, Color, Diameter, Evolutionused in North America)