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Experimental data also support the hepatoprotective effects of GSH
Levels of PPAT, the key enzyme of de novo purine nucleotide synthesis, are increased in TC tissues, enhancing PKM2 expression and activating extracellular signal-regulated kinase (ERK) and signal transducer of activation 3 (STAT3) signaling pathways [73]
AICAR is phosphorylated by cellular kinases to form ZMP, which acts as an AMP mimetic that directly binds and activates AMPK [42, 43]
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When the salt concentration decreases, more hydrophilic proteins are released first, followed by more hydrophobic proteins
Blood 107:21622169 [DOI] [PMC free article] [PubMed] [Google Scholar] Higuchi S, Matsushita S, Murayama M, Takagi S, Hayashida M
