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The three-dimensional structure is arranged in a three-layer, antiparallel -helical sandwich (PDB: 1E3G) fold that is characteristic of NR LBDs

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Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use: Clinical symptoms of hyperammonemic encephalopathy often include acute alterations in level of consciousness and/or cognitive function with lethargy or vomiting

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Additionally, while semaglutide generally has a favorable liver safety profile and has been approved (as Wegovy) for treating metabolic dysfunction-associated steatohepatitis (MASH) with moderate-to-advanced fibrosis based on phase 3 trials showing histological improvements, rare post-marketing cases of hepatotoxicity (elevated liver enzymes, jaundice) have been reported, typically resolving upon discontinuation