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High prevalence of cobalamin deficiency in elderly outpatients

Subcutaneous injection (under the skin) is the most effective delivery method
The Increlex (mecasermin) FDA label, which covers native rhIGF-1 in pediatric severe primary IGFD, is the closest human reference and informs the contraindications below
A complete chemical synthesis of vitamin B12 was finally achieved in 1960 by an international consortium of chemists

[DOI] [PMC free article] [PubMed] [Google Scholar] 54.Peskar B.M., Respondek M., Muller K.M., Peskar B.E
